Page last updated: 5-MAY-2008

SUPREMO

SUPREMO logo(Selective Use of Postoperative Radiotherapy aftEr  MastectOmy)

A randomised phase III trial assessing the role of chest wall irradiation in women with intermediate risk breast cancer following mastectomy.

Study schema

SUPREMO study protocol

Objectives

Primary:

To determine the effect of ipsilateral chest wall irradiation following mastectomy and axillary clearance for women with operable breast cancer at ?intermediate risk? of loco-regional recurrence on overall survival.

Secondary:

To determine the effect of ipsilateral chest wall irradiation following mastectomy and axillary clearance for women with operable breast cancer at ?intermediate risk? of loco-regional recurrence in terms of:

  • Chest wall recurrence
  • Regional recurrence
  • Disease-free survival
  • Metastasis-free survival
  • Cause of death (Breast cancer, intercurrent disease [cardiovascular and non-cardiovascular])
  • Acute and late morbidity
  • Quality of life
  • Cost effectiveness

Sub studies:

  • Biological sub study (TRANS-SUPREMO)
  • Cardiac sub study (UK only)
  • Quality of life sub study (UK only)
  • Health economic sub study (UK only)

Target accrual: 3700

Trial opened in UK: June 2006
Trial opened in EORTC: April 2007

Current accrual in UK: 134 patients
Current accrual in EORTC: 20 patients

 


 


Main contact: Email SUPREMO